OECD SIDS                                                        SODIUM DEDOCYL SULFATE

 

 

FOREWORD                                             INTRODUCTION

 

 

SODIUM DODECYL SULFATE

CAS N: 151-21-3

 

 

 

 

SIDS INITIAL ASSESSMENT PROFILE

CAS NO

151-21-3

Chemical Name

Sodium dodecyl sulfate (SDS)

Structural formula

CH3-(CH2)11-O-SO3-Na+

RECOMMENDATION OF THE SPONSOR COUNTRY

[ X ] presently of low priority for further work

[ ] requiring further information to assess identified concerns

[ ] candidate for in-depth risk assessment with a view to possible risk reduction activities

(1) Based on an initial assessment of the effect and exposure data provided in the SIDS dossier, the chemical can be considered to present a low potential for risk to man and the environment. Thus there is no current priority for undertaking post-SIDS testing and/or exposure analysis or an in-depth assessment.

SHORT SUMMARY WHICH SUPPORT THE REASONS FOR THE RECOMMENDATIONS

The production volume of SDS is ca. 10,000 t/y in Germany. SDS is used as a surfactant in detergents, dispersants, cosmetics and toiletry. SDS is classified as "readily biodegradable" with "low bioaccumulation". The most sensitive environmental species to SDS is the clam Corbicula fluminea (30d-NOEC = 0.65 mg/l).

All relevant toxicity endpoints are covered. SDS is a substance of low toxicity. The substance did not induce mutations in different test systems. The lowest NOAEL was established for repeated dose toxicity, being 100 mg/kg bw/day.

The aquatic local PEC was estimated to be 2.3 g/l, additional to a "background" regional PEC of further 2.3 g/l.

It is calculated that adult consumers may be exposed to up to 0.030 mg/kg/day and that babies may be exposed to 0.034 mg/kg/day. The highest consumer exposure, however, is estimated to occur to children, with the worst case exposure being 0.160 mg/kg/day. Babies (ca. 0.25 mg/kg/day) and adults (ca. 0.05 mg/kg/day) are exposed to a lesser extent. Occupational exposure is calculated to be about 0.100 mg/kg/day, and the combined consumer and occupational exposure for workers is about 0.130 mg/kg/day.

Based on the NOEC of 0.65 mg/l, a risk to the aquatic compartment is not to be expected.

A safety margin for worst case human exposure (children) of > 600 was established in the risk assessment. Taking into account the quality and quantity of the toxicological data and the kind of health effects observed (mild hepatotoxicity), a safety margin of > 600 is considered sufficient. Therefore, it is concluded that sodium dodecyl sulfate is of no concern with respect to human health.

IF FURTHER WORK IS RECOMMENDED, SUMMARISE ITS NATURE

none

FULL SIDS SUMMARY

CAS-NO.: 151-21-3 SPECIES PROTOCOL RESULTS
PHYSICAL CHEMICAL
2.1 Melting Point  

NA

204-207 C
2.2 Boiling Point  

/

/ C (at kPa)
2.3 Density  

NA

400-600 kg/m3
2.4 Vapour Pressure  

/

/ kPa at C
2.5 Partition Coefficient (Log Pow)  

NA (calc)

1.6
2.6 A Water solubility  

NA

150000 mg/l atC
B pH     6-9 at 10 g/l at 20 C
  pKa  

/

/
2.12 Oxidation : Reduction potential  

/

/ mV
ENVIRONMENTAL FATE / BIODEGRADATION
3.1.1 Photodegradation  

ND

In air T1/2 = / hour
3.1.2 Stability in water  

ND

T1/2 = /min
3.2 Monitoring data  

/

 
3.3 Transport and Distribution   estimated preferred compartment:

hydrosphere

     

NA

BCF: 2.1 - 7.1
     

NA

water-sediment:

K = 70-100 l/kg

3.5 Biodegradation  

OECD 301

readily biodegradable
     

OECD Conf. test

elimination > 99%
     

OECD 303A

elimination > 96%
         
ECOTOXICOLOGY (lowest effect concentrations only)
4.1 acute/prolonged toxicity to fish Macrones vittatus

NA

LC50 (96 hr) =1.39 mg/l
    Menidia beryllina

EPA-600/4-87/028

(larvae)

LC50 (7 d) = 1.8 mg/l
    Saccobranchus fossilis

NA

NOEC (60d) =>= 2.24 mg/l
4.2 acute/prolonged toxicity to aquatic invertebrates (daphnia) Homarus americanus

NA

EC50 (96 hr) =0.72 mg/l
    Brachionus rubens

EPA-600/4-85/013

EC50 (24 hr) =1.35 mg/l
    Corbicula fluminea

NA

NOEC (60d) = 0.65 mg/l

 

CAS-NO.: 151-21-3 SPECIES PROTOCOL RESULTS
ECOTOXICITY
4.3 toxicity to aquatic plants
e. g. algae
Sel. capri-cornutum

NA

EC50 (8 d) = 3.75 mg/l
    Champia parvula

EPA-600/4-87/028

EC50 (48 hr) =0.3 mg/l
4.4 toxicity to microorganisms Photobact. phosphoreum

Microtox

EC50 (15 min) =0.38 mg/l
    Uronema parduczi

NA

TT (EC3) (20h) =0.75 mg/l
4.5.2 chronic toxicity to aquatic invertebrates ( daphnia ) Daphnia magna

EPA-600/3-75-009

NOEC (40d) = 2 mg/l
4.6.2 toxicity to terrestrial plants Cicer arietinum

NA

EC50 (48 hr) =361 mg/l
TOXICOLOGY
5.1.1 acute oral toxicity

rat

NA

LD50 = 1200 mg/kg
5.1.3 acute dermal toxicity

rabbit

guinea pig

NA

NA

LD50 = ca. 600 mg/kg

LD50 = >1200 mg/kg

5.4 repeated dose toxicity

rat

NA

NOAEL= 100 mg/kg/day

(hepatotoxicity)

5.5 genetic toxicity in vitro      
  bacterial test (gene mutation)

S. typhimurium

Ames test

negative (with and without

metabolic activation)

  non-bacterial test (gene-mutation)

mice

Lymphoma cell forward mutation assay

negative (with and without

metabolic activation)

  non-bacterial test
(indicator test for gene and/or chromosome mutation)

Chinese hamster

Sister chromatid exchange

negative (with and without

metabolic activation)

5.6 genetic toxicity in vivo (chromosome aberration)

rat

Micronucleus assay

negative
5.8 toxicity to reproduction

mice

  NOAEL = 1000mg/kg/day

(male fertility)

5.9 developmental toxicity / teratogenicity

mice rabbits

  NOAEL 300 mg/kg/day

(maternal toxicity)
NOAEL = 400 mg/kg/day (resorption/litter loss)
NOAEL =600 mg/kg/day

(foetal malformation)

5.11 experience with human exposure In experimental ulcer treatment up to 80 mg/kg/day (highest dose

tested) were tolerated without adverse side effects.

Up to 1 % are considered safe for cosmetic non-rinse-off products.