OECD SIDS                                          N,N-DIMETHYLAMINO-2-ETHANOL

 

 

 

    FORWORD                                                    INTRODUCTION

 

 

 

N,N-DIMETHYLAMINO-2-ETHANOL

CAS N: 108-01-0

 

 

 

 

SIDS INITIAL ASSESSMENT PROFILE

CAS-NO

108-01-0

CHEMICAL NAME

N,N-DIMETHYLAMINO-2-ETHANOL

STRUCTURAL FORMULA

(CH3)2NCH2CH2OH

RECOMMENDATION OF THE SPONSOR COUNTRY

[X] presently of low priority for further work

[ ] requiring further information to assess identified concerns

[ ] candidate for in-depth risk assessment with a view to possible risk reduction activities

SHORT SUMMARY OF THE REASONS WHICH SUPPORT THE RECOMMENDATION

Environment - Dimethylaminoethanol may be released to air and to water, where it will degrade fairly rapidly. It tends not to move from the phase to which it is released. It is of moderate toxicity to aquatic organisms; some of its toxicity may be due to changes in pH when it dissolves in water.

Estimated release to water from production via sewage treatment plant based on default values for the size of the sewage plant and the receiving river leads to concern for the aquatic environment; however dilution at actual sites is thought to be much greater, leading to no concern.

Human health - Dimethylaminoethanol is of low single exposure toxicity but has corrosive properties. It is not genotoxic or toxic to development or the reproductive system.

IF FURTHER WORK IS RECOMMENDED, SUMMARISE ITS NATURE

No further toxicity tests are required.

Information on production sites and use in corrosion inhibitor formulations would be useful to confirm the assessment. Data on these areas were requested after SIAM 3; as the subsequent information collection exercise did not produce further specific data it is not proposed to actively seek further information.

The additional exposure data provided by other Member States on the occupational and consumer end-points does not change the overall assessment of the substance as being of low risk for human health based on existing control measures.

The UK has produced a more detailed occupational risk assessment for domestic use, resulting in the following occupational exposure limits: 2 ppm 8 hour TWA and 6 ppm for a short 15 minute exposure for irritancy. Copies can be made available on request.