OECD SIDS                                      BUTANEDIOIC ACID, METHYLENE  

 

 

FOREWORD                                    INTODUCTION

 

 

BUTANEDIOIC ACID, METHYLENE  

CAS N: 97-65-4

 

 

 

 

SIDS INITIAL ASSESSMENT PROFILE

CAS-NO

97-65-4

CHEMICAL NAME

Butanedioic acid, methylene

STRUCTURAL FORMULA

    CH2-COOH
CH2=C-COOH 

RECOMMENDATION OF THE SPONSOR COUNTRY

[ X ] presently of low priority for further work

[ ] requiring further information to assess identified concerns

[ ] candidate for in-depth risk assessment with a view to possible risk reduction activities

SHORT SUMMARY OF THE REASONS WHICH SUPPORT THE RECOMMENDATION

The worldwide production of butanedioic acid, methylene is about 15 000 tonnes per year. It is used as a comonomer for synthesis of acrylic fibers and latex.

From the comparison of PEC and NEC in aquatic and terrestrial compartments, it can be concluded that the chemical is of no concern for the environment.

Normal industrial hygiene practice should adequately protect the worker in itaconic production and use facilities.

IF FURTHER WORK IS RECOMMENDED, SUMMARISE ITS NATURE

FULL SIDS SUMMARY

CAS No: 97-65-4 SPECIES PROTOCOL RESULTS
PHYSICAL-CHEMICAL
2.1 Melting Point 165-169C
2.2 Boiling Point 268C
2.3 Density -
2.4 Vapour Pressure -
2.5 Partition Coefficient (Log Pow) OECD 107 -0.4 at 25C
2.6a. Water Solubility 83 g/l at 20C
2.6b. pH 2 (80 mg/l)
pKa *3.84
2.12 Oxidation: Reduction Potential -
ENVIRONMENTAL FATE/DEGRADATION
3.1.1 Photodegradation
3.1.2 Stability in water
3.2 Monitoring data
3.3 Transport and Distribution
3.5 Biodegradation EEC 84/449 Modified OECD screening test

GLP

96% in 13 d

 

CAS No. 97-65-4 SPECIES PROTOCOL RESULTS
ECOTOXICOLOGY
4.1 Acute/Prolonged Toxicity to Fish Salmo gardineri EEC 84/449-C1-GLP LC50 (24 h) = 190 mg/l
4.2 Acute Toxicity to Aquatic Invertebrates: Daphnia Daphnia magna EEC 84/449-C2-GLP EC50 (24 h) = 240 mg/l
4.3 Toxicity to Aquatic Plants eg. Algae Scenidesmus subspicatus EEC 87/302

GLP

EC50 (72 h) = 47 mg/l
4.5.2 Chronic Toxicity to Aquatic Invertebrates (Daphnia) -
4.6.1 Toxicity to Soil Dwelling Organisms -
4.6.2 Toxicity to Terrestrial Plants -
4.6.3 Toxicity to Other Non Mammalian Terrestrial Species (Including Birds) -
TOXICOLOGY
5.1.1 Actue oral toxicity Rat EEC 84/449-B1 GLP LD50 = 2969 mg/kg
5.1.2 Acute inhalation toxicity
5.1.3 Actue dermal toxicity Rat EEC 84/449-B3 GLP LD0>2000 mg/kg
5.4 Repeated dose toxicity Rat EEC 84/449-B7 GLP

EEC 87/302 GLP

Oral, 4w: NOEL = 500 mg/kg/d (highest dose tested)

Oral, 13w: NOEL = 14000 ppm (1050 mg/kg/d)

5.5 Genetic toxicity in vitro
a. Bacterial test (gene mutation) Ames EEC 84/449-B4 GLP Negative +/- S9 mix
b. Non bacterial in vitro test HPRT/V79 CHO OECD 476 GLP Negative +/- S9 mix
5.6 Genetic toxicity in vivo Mice/Swiss EEC 84/449 GLP Negative +/- S9 mix
5.8 Toxicity to reproduction
5.9 Developmental toxicity/teratogenicity Rat OECD 415 GLP **Foetuses: NOEL=1000 mg/kg/d

Dams: NOAEL=1000 mg/kg/d

5.11 Experience with human exposure

*Ref.: Patty, F. (ED. Industrial hygiene and toxicology, Interscience publishers, 1963)
** New test